About The Medical Condition Aflatoxin M1
Find the definition of the medical term Aflatoxin M1. Aflatoxin M1 defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Aflatoxin M1
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What's The Definition Of The Medical Condition Aflatoxin M1?
A 4-hydroxylated metabolite of AFLATOXIN B1, one of the MYCOTOXINS from ASPERGILLUS tainted food. It is associated with LIVER damage and cancer resulting from its P450 activation to the epoxide which alkylates DNA. Toxicity depends on the balance of liver enzymes that activate it (CYTOCHROME P-450) and others that detoxify it (GLUTATHIONE S TRANSFERASE) (Pharmac Ther 50.443 1991). Primates & rat are sensitive while mouse and hamster are tolerant (Canc Res 29.236 1969).
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