About The Medical Condition Alpha Genes, TR
Find the definition of the medical term Alpha Genes, TR. Alpha Genes, TR defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Alpha Genes, TR
| Alpha Genes, TR Medical Condition |
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What's The Definition Of The Medical Condition Alpha Genes, TR?
Retrovirus-associated DNA sequences (ERYTHROBLASTOSIS VIRUS, AVIAN, hence erbA) originally isolated from the avian erythroblastosis virus. The c-erbA proto-oncogene encodes the thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA proto-oncogenes have been identified, erbA-alpha and erbA-beta, each giving rise to at least two proteins. erbA-alpha is located at 17q21 on the long arm of chromosome 17. erbA-beta is located at 3p24 on the short arm of chromosome 3. The v-erbA oncogene potentiates cell transformation through inhibition of spontaneous differentiation of cells already transformed by the v-erbB gene and eliminates growth requirements of transformed erythroblasts.
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