About The Medical Condition Amyloid A4 Protein Precursor
Find the definition of the medical term Amyloid A4 Protein Precursor. Amyloid A4 Protein Precursor defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Amyloid A4 Protein Precursor
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What's The Definition Of The Medical Condition Amyloid A4 Protein Precursor?
A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
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