About The Medical Condition Antineoplastics, Alkylating
Find the definition of the medical term Antineoplastics, Alkylating. Antineoplastics, Alkylating defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Antineoplastics, Alkylating
| Antineoplastics, Alkylating Medical Condition |
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What's The Definition Of The Medical Condition Antineoplastics, Alkylating?
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
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