About The Medical Condition ATP-Binding Cassette, Sub-Family B Proteins
Find the definition of the medical term ATP-Binding Cassette, Sub-Family B Proteins. ATP-Binding Cassette, Sub-Family B Proteins defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
ATP-Binding Cassette, Sub-Family B Proteins
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What's The Definition Of The Medical Condition ATP-Binding Cassette, Sub-Family B Proteins?
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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