About The Medical Condition Autonomic Failure, Progressive
Find the definition of the medical term Autonomic Failure, Progressive. Autonomic Failure, Progressive defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Autonomic Failure, Progressive
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What's The Definition Of The Medical Condition Autonomic Failure, Progressive?
A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord, which differentiates this condition from other forms of idiopathic orthostatic hypotension (HYPOTENSION, ORTHOSTATIC). This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with orthostasis and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)
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