About The Medical Condition Charcot-Marie-Tooth Disease, Type I

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Find the definition of the medical term Charcot-Marie-Tooth Disease, Type I. Charcot-Marie-Tooth Disease, Type I defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Charcot-Marie-Tooth Disease, Type I

Charcot-Marie-Tooth Disease, Type I Medical Condition Defined & Explained
Charcot-Marie-Tooth Disease, Type I Medical Condition

What's The Definition Of The Medical Condition Charcot-Marie-Tooth Disease, Type I?

A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343)

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