About The Medical Condition Cilastatin
Find the definition of the medical term Cilastatin. Cilastatin defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Cilastatin
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What's The Definition Of The Medical Condition Cilastatin?
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukeotriene E4.
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