About The Medical Condition Class I Major Histocompatibility Antigens
Find the definition of the medical term Class I Major Histocompatibility Antigens. Class I Major Histocompatibility Antigens defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Class I Major Histocompatibility Antigens
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What's The Definition Of The Medical Condition Class I Major Histocompatibility Antigens?
Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.
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