About The Medical Condition Class II Major Histocompatibility Antigens
Find the definition of the medical term Class II Major Histocompatibility Antigens. Class II Major Histocompatibility Antigens defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Class II Major Histocompatibility Antigens
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What's The Definition Of The Medical Condition Class II Major Histocompatibility Antigens?
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
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