About The Medical Condition Deficiency Disease, Arylsulfatase A

ClusterMed
  1. ClusterMed.info
  2. Medical Conditions
  3. D Illnesses And Diseases
  4. De
  5. Deficiency Disease, Arylsulfatase A

Find the definition of the medical term Deficiency Disease, Arylsulfatase A. Deficiency Disease, Arylsulfatase A defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Deficiency Disease, Arylsulfatase A

Deficiency Disease, Arylsulfatase A Medical Condition Defined & Explained
Deficiency Disease, Arylsulfatase A Medical Condition

What's The Definition Of The Medical Condition Deficiency Disease, Arylsulfatase A?

An autosomal recessive lysosomal storage disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to an accumulation of cerebroside sulfate in the nervous system and other organs. Pathologic features include diffuse demyelination and metachromatically-staining granules within glial cells, macrophages, and free in tissue. Clinical subtypes include late infantile, juvenile, and adult forms. The late infantile form presents at 12-18 months of age with progressive psychomotor retardation, ATAXIA, spasticity, and OPTIC ATROPHY. The juvenile form has onset at 4-12 years and features behavioral alterations and ataxia followed by spasticity, DEMENTIA, and visual loss. The adult form presents in the second decade or later with psychiatric manifestations, gait difficulties, and less often as a peripheral neuropathy. (From Menkes, Textbook of Child Neurology, 5th ed, pp192-5)

More Medical Conditions

A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z

Medical Conditions Definitions Of The Day