Deficiency Diseases, alpha-L-Fucosidase Medical Condition Defined & Explained

About The Medical Condition Deficiency Diseases, alpha-L-Fucosidase

Find the definition of the medical term Deficiency Diseases, alpha-L-Fucosidase. Deficiency Diseases, alpha-L-Fucosidase defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Deficiency Diseases, alpha-L-Fucosidase

Deficiency Diseases, alpha-L-Fucosidase Medical Condition
What's The Definition Of The Medical Condition Deficiency Diseases, alpha-L-Fucosidase? An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS, GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)

Deficiency Diseases, alpha-L-Fucosidase Medical Condition

What's The Definition Of The Medical Condition Deficiency Diseases, alpha-L-Fucosidase?

An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS, GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)

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