About The Medical Condition Dihydrofolate Dehydrogenase
Find the definition of the medical term Dihydrofolate Dehydrogenase. Dihydrofolate Dehydrogenase defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Dihydrofolate Dehydrogenase
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What's The Definition Of The Medical Condition Dihydrofolate Dehydrogenase?
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
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