About The Medical Condition Dihydrofolate Reductase
Find the definition of the medical term Dihydrofolate Reductase. Dihydrofolate Reductase defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Dihydrofolate Reductase
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What's The Definition Of The Medical Condition Dihydrofolate Reductase?
An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
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