About The Medical Condition EAN (Experimental Allergic Neuritis)
Find the definition of the medical term EAN (Experimental Allergic Neuritis). EAN (Experimental Allergic Neuritis) defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
EAN (Experimental Allergic Neuritis)
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What's The Definition Of The Medical Condition EAN (Experimental Allergic Neuritis)?
An experimental animal demyelinating disease model of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
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