About The Medical Condition Endothelium-Derived Relaxing Factor
Find the definition of the medical term Endothelium-Derived Relaxing Factor. Endothelium-Derived Relaxing Factor defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Endothelium-Derived Relaxing Factor
| Endothelium-Derived Relaxing Factor Medical Condition |
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What's The Definition Of The Medical Condition Endothelium-Derived Relaxing Factor?
A free radical gas produced endogenously by a variety of mammalian cells. It is synthesized from arginine by a complex reaction, catalyzed by NITRIC OXIDE SYNTHASE. Nitric oxide is endothelium-derived relaxing factor. It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP.
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