About The Medical Condition ErbA Oncogene Proteins
Find the definition of the medical term ErbA Oncogene Proteins. ErbA Oncogene Proteins defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
ErbA Oncogene Proteins
| ErbA Oncogene Proteins Medical Condition |
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What's The Definition Of The Medical Condition ErbA Oncogene Proteins?
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
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