About The Medical Condition Familial Hypoalphalipoproteinemias
Find the definition of the medical term Familial Hypoalphalipoproteinemias. Familial Hypoalphalipoproteinemias defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Familial Hypoalphalipoproteinemias
| Familial Hypoalphalipoproteinemias Medical Condition |
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What's The Definition Of The Medical Condition Familial Hypoalphalipoproteinemias?
A rare autosomal recessive familial disorder of cholesterol metabolism, characterized by extremely low HDL-cholesterol, reduced total cholesterol, and increased triglyceride levels in serum. Clinical features include the onset before age 20 years of HEPATOMEGALY; SPLENOMEGALY; the deposition of cholesterol in each TONSIL (creating a yellow-orange appearance); and RETINITIS PIGMENTOSA. A sensorimotor or distal sensory POLYNEUROPATHY occurs in approximately 50% of affected individuals. The condition is associated with decreased synthesis and increased catabolism of APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II, and a defect in cellular signaling and mobilization of lipids. (From Nat Genet 1998 Sep;20(1):96-8; Adams et al., Principles of Neurology, 6th ed, pp1347-8; Menkes, Textbook of Child Neurology, 5th ed, p118)
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