About The Medical Condition Fms Oncogene Product gp140
Find the definition of the medical term Fms Oncogene Product gp140. Fms Oncogene Product gp140 defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Fms Oncogene Product gp140
| Fms Oncogene Product gp140 Medical Condition |
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What's The Definition Of The Medical Condition Fms Oncogene Product gp140?
Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
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