About The Medical Condition GABA Modulators
Find the definition of the medical term GABA Modulators. GABA Modulators defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
GABA Modulators
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What's The Definition Of The Medical Condition GABA Modulators?
Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. General anesthetics probably act at least partly by potentiating GABAergic responses, but they are not included here.
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