About The Medical Condition Gamma-Chain Disease
Find the definition of the medical term Gamma-Chain Disease. Gamma-Chain Disease defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Gamma-Chain Disease
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What's The Definition Of The Medical Condition Gamma-Chain Disease?
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
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