About The Medical Condition Gene, erbB1
Find the definition of the medical term Gene, erbB1. Gene, erbB1 defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Gene, erbB1
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What's The Definition Of The Medical Condition Gene, erbB1?
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
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