About The Medical Condition Genes, MDR
Find the definition of the medical term Genes, MDR. Genes, MDR defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Genes, MDR
| Genes, MDR Medical Condition |
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What's The Definition Of The Medical Condition Genes, MDR?
Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene familes. The human multidrug resistance 1; (MDR1); gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199(3):1428-35; Cancer Res 1994:54(6):1536-41)
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