About The Medical Condition Globoid Cell Leukodystrophy

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Find the definition of the medical term Globoid Cell Leukodystrophy. Globoid Cell Leukodystrophy defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Globoid Cell Leukodystrophy

Globoid Cell Leukodystrophy Medical Condition Defined & Explained
Globoid Cell Leukodystrophy Medical Condition

What's The Definition Of The Medical Condition Globoid Cell Leukodystrophy?

An autosomal recessive inherited sphingolipidosis caused by a deficiency of GALACTOSYLCERAMIDASE leading to an accumulation of PSYCHOSINE in LYSOSOMES of the BRAIN; PERIPHERAL NERVES; LIVER; KIDNEY; and LEUKOCYTES. In the nervous sytem there is prominent central and peripheral demyelination. The infantile form presents at age 4-6 months with psychomotor retardation, MUSCLE SPASTICITY, and tonic spasms induced by minor stimuli. Death occurs within two years. Later onset forms of this disease are characterized by a less fulminant course. (From Menkes, Textbook of Child Neurology, 5th ed, pp195-7)

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