About The Medical Condition Heavy Chain Disease
Find the definition of the medical term Heavy Chain Disease. Heavy Chain Disease defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Heavy Chain Disease
| Heavy Chain Disease Medical Condition |
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What's The Definition Of The Medical Condition Heavy Chain Disease?
A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
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