About The Medical Condition Heparin Neutralizing Protein
Find the definition of the medical term Heparin Neutralizing Protein. Heparin Neutralizing Protein defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Heparin Neutralizing Protein
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What's The Definition Of The Medical Condition Heparin Neutralizing Protein?
A high-molecular-weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin. It acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation. At high ionic strength (I=0.75), the complex dissociates into the active component (molecular weight 29,000) and the proteoglycan carrier (chondroitin 4-sulfate, molecular weight 350,000). The molecule exists in the form of a dimer consisting of 8 moles of platelet factor 4 and 2 moles of proteoglycan.
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