About The Medical Condition Histocompatibility Antigens Class I

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Find the definition of the medical term Histocompatibility Antigens Class I. Histocompatibility Antigens Class I defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

Histocompatibility Antigens Class I

Histocompatibility Antigens Class I Medical Condition Defined & Explained
Histocompatibility Antigens Class I Medical Condition

What's The Definition Of The Medical Condition Histocompatibility Antigens Class I?

Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders.

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