About The Medical Condition Hyperkalemic Periodic Paralysis, Familial
Find the definition of the medical term Hyperkalemic Periodic Paralysis, Familial. Hyperkalemic Periodic Paralysis, Familial defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Hyperkalemic Periodic Paralysis, Familial
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What's The Definition Of The Medical Condition Hyperkalemic Periodic Paralysis, Familial?
An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
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