About The Medical Condition Immunodeficient Mice, Severe Combined
Find the definition of the medical term Immunodeficient Mice, Severe Combined. Immunodeficient Mice, Severe Combined defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Immunodeficient Mice, Severe Combined
| Immunodeficient Mice, Severe Combined Medical Condition |
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What's The Definition Of The Medical Condition Immunodeficient Mice, Severe Combined?
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
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