About The Medical Condition Immunoglobulin Receptor, Polymeric
Find the definition of the medical term Immunoglobulin Receptor, Polymeric. Immunoglobulin Receptor, Polymeric defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Immunoglobulin Receptor, Polymeric
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What's The Definition Of The Medical Condition Immunoglobulin Receptor, Polymeric?
Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)
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