About The Medical Condition Inhibitor, Collagenase
Find the definition of the medical term Inhibitor, Collagenase. Inhibitor, Collagenase defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Inhibitor, Collagenase
Inhibitor, Collagenase Medical Condition |
---|
What's The Definition Of The Medical Condition Inhibitor, Collagenase?
A family of secreted proteins (TIMP-1; TIMP-2; and TIMP-3) that play a crucial role in regulating the activity of the secreted METALLOENDOPEPTIDASES (COLLAGENASES; stromelysins, GELATINASES). Of the three characterized, only TIMP-1 and TIMP-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)
|
More Medical Conditions
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
Medical Conditions Definitions Of The Day
- Limit Dextrinosis ‐ An autosomal recessive metabolic disorder due to deficient expression…
- Deductibles and Coinsurance ‐ Cost-sharing mechanisms that provide for payment by the insured…
- Sequence Analysis ‐ A multistage process that includes the determination of a sequence…
- Cell Death, Programmed ‐ One of the two mechanisms by which CELL DEATH occurs (the other…
- Hemispatial Neglect ‐ Cognitive disorders characterized by an impaired ability to perceive…
- Deficiency, IgA ‐ A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN…
- Platelet Adhesiveness ‐ The process whereby platelets adhere to something other than…
- Carcinomas, Anaplastic ‐ A malignant neoplasm made up of epithelial cells tending to infiltrate…
- Joint Prosthesis Implantations ‐ Partial or total replacement…
- Identity Disorder, Dissociative ‐ A dissociative disorder in which the individual adopts two or…