About The Medical Condition Isocitrate Dehydrogenase-I
Find the definition of the medical term Isocitrate Dehydrogenase-I. Isocitrate Dehydrogenase-I defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Isocitrate Dehydrogenase-I
| Isocitrate Dehydrogenase-I Medical Condition |
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What's The Definition Of The Medical Condition Isocitrate Dehydrogenase-I?
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
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