About The Medical Condition Isocitrate Dehydrogenase
Find the definition of the medical term Isocitrate Dehydrogenase. Isocitrate Dehydrogenase defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Isocitrate Dehydrogenase
| Isocitrate Dehydrogenase Medical Condition |
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What's The Definition Of The Medical Condition Isocitrate Dehydrogenase?
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
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