About The Medical Condition Kininogens, High-Molecular-Weight
Find the definition of the medical term Kininogens, High-Molecular-Weight. Kininogens, High-Molecular-Weight defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Kininogens, High-Molecular-Weight
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What's The Definition Of The Medical Condition Kininogens, High-Molecular-Weight?
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
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