About The Medical Condition Lambert-Eaton Syndrome
Find the definition of the medical term Lambert-Eaton Syndrome. Lambert-Eaton Syndrome defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Lambert-Eaton Syndrome
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What's The Definition Of The Medical Condition Lambert-Eaton Syndrome?
An autoimmune disease characterized by weakness and fatigability of proximal muscles, particularly of the pelvic girdle, lower extremities, trunk, and shoulder girdle. There is relative sparing of extraocular and bulbar muscles. CARCINOMA, SMALL CELL of the lung is a frequently associated condition, although other malignancies and autoimmune diseases may be associated. Muscular weakness results from impaired impulse transmission at the NEUROMUSCULAR JUNCTION. Presynaptic calcium channel dysfunction leads to a reduced amount of acetylcholine being released in response to stimulation of the nerve. (From Adams et al., Principles of Neurology, 6th ed, pp 1471)
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