About The Medical Condition Late-Onset Huntington Disease
Find the definition of the medical term Late-Onset Huntington Disease. Late-Onset Huntington Disease defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Late-Onset Huntington Disease
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What's The Definition Of The Medical Condition Late-Onset Huntington Disease?
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse CHOREA involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
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