About The Medical Condition Lateral Scleroses, Amyotrophic
Find the definition of the medical term Lateral Scleroses, Amyotrophic. Lateral Scleroses, Amyotrophic defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Lateral Scleroses, Amyotrophic
| Lateral Scleroses, Amyotrophic Medical Condition |
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What's The Definition Of The Medical Condition Lateral Scleroses, Amyotrophic?
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
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