About The Medical Condition Leigh Disease, Infantile
Find the definition of the medical term Leigh Disease, Infantile. Leigh Disease, Infantile defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Leigh Disease, Infantile
Leigh Disease, Infantile Medical Condition |
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What's The Definition Of The Medical Condition Leigh Disease, Infantile?
A group of metabolic disorders primarily of infancy characterized by the subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, dysphagia, and lactic acidosis. Pathological features include spongy degeneration of the neuropile of the basal ganglia, thalamus, brain stem, and spinal cord. Patterns of inheritance include X-linked recessive, autosomal recessive, and mitochondrial. Leigh disease has been associated with mutations in genes for the PYRUVATE DEHYDROGENASE COMPLEX; CYTOCHROME-C OXIDASE; ATP synthase subunit 6; and subunits of mitochondrial complex I. (From Menkes, Textbook of Child Neurology, 5th ed, p850).
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