About The Medical Condition LOH
Find the definition of the medical term LOH. LOH defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
LOH
| LOH Medical Condition |
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What's The Definition Of The Medical Condition LOH?
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair. It is detected when heterozygous markers for a locus appear monomorphic because one of the alleles was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal, it can result in neoplastic transformation.
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