About The Medical Condition Loss of Heterozygosity
Find the definition of the medical term Loss of Heterozygosity. Loss of Heterozygosity defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Loss of Heterozygosity
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What's The Definition Of The Medical Condition Loss of Heterozygosity?
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair. It is detected when heterozygous markers for a locus appear monomorphic because one of the alleles was deleted. When this occurs at a tumor suppressor gene locus where one of the alleles is already abnormal, it can result in neoplastic transformation.
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