About The Medical Condition Low Density Lipoprotein Receptor
Find the definition of the medical term Low Density Lipoprotein Receptor. Low Density Lipoprotein Receptor defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Low Density Lipoprotein Receptor
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What's The Definition Of The Medical Condition Low Density Lipoprotein Receptor?
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1) receptors do not bind to LDL; 2) there is reduced binding of LDL; and 3) there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
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