About The Medical Condition MAP Kinase Cascade

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Find the definition of the medical term MAP Kinase Cascade. MAP Kinase Cascade defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.

MAP Kinase Cascade

MAP Kinase Cascade Medical Condition Defined & Explained
MAP Kinase Cascade Medical Condition

What's The Definition Of The Medical Condition MAP Kinase Cascade?

An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.

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