About The Medical Condition Multidrug Resistance Proteins
Find the definition of the medical term Multidrug Resistance Proteins. Multidrug Resistance Proteins defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Multidrug Resistance Proteins
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What's The Definition Of The Medical Condition Multidrug Resistance Proteins?
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
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