About The Medical Condition Multifocal Leukoencephalopathies, Progressive
Find the definition of the medical term Multifocal Leukoencephalopathies, Progressive. Multifocal Leukoencephalopathies, Progressive defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Multifocal Leukoencephalopathies, Progressive
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What's The Definition Of The Medical Condition Multifocal Leukoencephalopathies, Progressive?
An opportunistic viral infection of the central nervous system associated with conditions that impair cell-mediated immunity (e.g., ACQUIRED IMMUNODEFICIENCY SYNDROME and other IMMUNOLOGIC DEFICIENCY SYNDROMES; HEMATOLOGIC NEOPLASMS; IMMUNOSUPPRESSION; and COLLAGEN DISEASES). The causative organism is JC Polyomavirus (JC VIRUS) which primarily affects oligodendrocytes, resulting in multiple areas of demyelination. Clinical manifestations include DEMENTIA; ATAXIA; visual disturbances; and other focal neurologic deficits, generally progressing to a vegetative state within 6 months. (From Joynt, Clinical Neurology, 1996, Ch26, pp36-7)
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