About The Medical Condition Neuroleptic Malignant Syndromes
Find the definition of the medical term Neuroleptic Malignant Syndromes. Neuroleptic Malignant Syndromes defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Neuroleptic Malignant Syndromes
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What's The Definition Of The Medical Condition Neuroleptic Malignant Syndromes?
A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
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