About The Medical Condition NSC-141540
Find the definition of the medical term NSC-141540. NSC-141540 defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
NSC-141540
| NSC-141540 Medical Condition |
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What's The Definition Of The Medical Condition NSC-141540?
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
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