About The Medical Condition Oncogene Products v-erbA

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Oncogene Products v-erbA

Oncogene Products v-erbA Medical Condition Defined & Explained
Oncogene Products v-erbA Medical Condition

What's The Definition Of The Medical Condition Oncogene Products v-erbA?

Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.

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