About The Medical Condition Oncogene Proteins v-erbA
Find the definition of the medical term Oncogene Proteins v-erbA. Oncogene Proteins v-erbA defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Oncogene Proteins v-erbA
| Oncogene Proteins v-erbA Medical Condition |
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What's The Definition Of The Medical Condition Oncogene Proteins v-erbA?
Transforming proteins encoded by erbA oncogenes from the avian erythroblastosis virus. They are truncated versions of c-erbA, the thyroid hormone receptor (RECEPTORS, THYROID HORMONE) that have retained both the DNA-binding and hormone-binding domains. Mutations in the hormone-binding domains abolish the transcriptional activation function. v-erbA acts as a dominant repressor of c-erbA, inducing transformation by disinhibiting proliferation.
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