About The Medical Condition Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated
Find the definition of the medical term Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated. Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated
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What's The Definition Of The Medical Condition Paraneoplastic Cerebellar Degeneration, Anti-Yo-Associated?
Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)
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