About The Medical Condition Pelizaeus-Merzbacher Disease, Transitional
![ClusterMed ClusterMed](/images/clustermed.jpg)
Find the definition of the medical term Pelizaeus-Merzbacher Disease, Transitional. Pelizaeus-Merzbacher Disease, Transitional defined and explained for easy understanding at the Medical Conditions from ClusterMed.info.
Pelizaeus-Merzbacher Disease, Transitional
![Pelizaeus-Merzbacher Disease, Transitional Medical Condition Defined & Explained Pelizaeus-Merzbacher Disease, Transitional Medical Condition Defined & Explained](/images/medicaltermsdefinitions.jpg)
Pelizaeus-Merzbacher Disease, Transitional Medical Condition |
---|
What's The Definition Of The Medical Condition Pelizaeus-Merzbacher Disease, Transitional?
A rare, slowly progressive disorder of myelin formation. Subtypes are referred to as classic, congenital, transitional, and adult forms of this disease. The classic form is X-chromosome linked, has its onset in infancy and is associated with a mutation of the proteolipid protein gene. Clinical manifestations include TREMOR, spasmus nutans, roving eye movements, ATAXIA, spasticity, and NYSTAGMUS. Death occurs by the third decade of life. The congenital form has similar characteristics but presents early in infancy and features rapid disease progression. Transitional and adult subtypes have a later onset and less severe symptomatology. Pathologic features include patchy areas of demyelination with preservation of perivascular islands (trigoid appearance). (From Menkes, Textbook of Child Neurology, 5th ed, p190)
|
More Medical Conditions
A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
Medical Conditions Definitions Of The Day
- Aortic Coarctations ‐ Narrowing of the lumen of the aorta, caused by deformity of the…
- Gelada Baboons ‐ A genus of Old World monkeys of the subfamily CERCOPITHECINAE,…
- Detections, Signal (Psychology) ‐ Psychophysical technique that permits the estimation of the bias…
- Drug Toxicities ‐ Manifestations of the adverse effects of drugs administered therapeutically…
- Peptide Elongation Factor G ‐ Peptide Elongation Factor G catalyzes the translocation of peptidyl-tRNA…
- Systems, Vasomotor ‐ The neural systems which act on vascular smooth muscle to control…
- Platelet Activating Factor ‐ A phospholipid derivative formed by platelets, basophils, neutrophils,…
- Sialuria, Infantile Form ‐ Autosomal recessive neurodegenerative disorders caused by lysosomal…
- Spastic Paraparesis ‐ Mild or moderate loss of motor function accompanied by SPASTICITY…
- Cycles, Endometrial ‐ The period of the regularly recurring physiologic changes in…